A webinar series from ELDICO 

Interested in learning more about the captivating realm of 3D Electron Diffraction?        

21st webinar recording

Part 21

Title: 'Micro-electron diffraction applications in the investigation of amorphous phases prepared by mechanochemistry and the structural analysis of metal-organic frameworks'

Speaker: Dr. Silvina Pagola (Department of Chemistry and Biochemistry Old Dominion University, Virginia, USA)

About the webinar

3D electron diffraction (3D ED) analysis of amorphous phases prepared by mechanochemistry and the structural analysis of metal-organic frameworks

As part of her study Silvina discussed a novel use of ED to screen for poorly crystalline seeds of the salt that will grow from the bulk amorphous, leading to rapid crystallization once the powders are exposed to vapors of solvents, such as hexane, N,N-dimethylformamide, and acetonitrile, but very slow recrystallization if they are kept in close containers only exposed to air.

3D ED (ED, MicroED) is particularly useful to study mixed phases of single nanocrystals. Silvina collaborated with ELDICO Scientific to obtain the results that are shown in this webinar

These results are very valuable for the full characterization of formulated amorphous pharmaceuticals, for the investigation of their stability under long-term storage.

The results shown in the presentation are due to be published soon in collaboration with ELDICO Scientific


ELDICO Scientific AG (The Electron Diffraction Company) is a Swiss technology and service company founded in 2019 and based in the Switzerland Innovation Park Innovaare at the Paul Scherrer Institute (PSI), a world-leading research institute for natural sciences and engineering. ELDICO develops, manufactures and commercializes electron diffractometers, i.e. novel analytical instruments for electron based crystallography, enabling to investigate nano-crystalline samples. ELDICO launched the first instrument specifically designed for nano-crystallographic investigations. Proof-of-concept was achieved in 2018 (ETH Zurich, C-CINA Basel) as part of a Nano-Argovia project of the Swiss Nanoscience Institute (SNI). It was published in 2018 and awarded Top 5 "Breakthrough of the Year 2018" by the leading science magazine SCIENCE. In 2020 among other public recognitions on Swiss and EU level, ELDICO took 2nd place in the prestigious Pioneer Prize awarded by Technopark Zurich and the Zürcher Kantonalbank (ZKB). ELDICO’s clients are industrial and academic researchers in large and fast growing industries such as the pharmaceutical industry, the electromobility, and the advanced materials/MOF sector. The company partners with leading engineering companies and component suppliers, among which are Dectris and Excillum, to deliver superior performance. www.eldico-scientific.com