Unlocking the crystal structures of marketed drugs.
How 3D electron diffraction solved the long-missing structure of febuxostat – directly from nanocrystals.
What you'll learn
- How 3D ED determines structures from crystals too small for single-crystal X-ray diffraction
- How a marketed drug's long-missing crystal structure was solved from nanocrystalline material
- Why complete structural data underpins stability, formulation and IP strategy
Why it matters
Many marketed drugs still lack a determined crystal structure because their crystals are too small for single-crystal X-ray diffraction – leaving gaps in the solid-state knowledge that governs stability, formulation and regulatory and IP strategy. This note shows how the ELDICO ED-1 solved the long-missing structure of febuxostat directly from nanocrystals.
At a glance: 3D ED / MicroED · febuxostat (marketed drug) · nanocrystalline material · long-missing structure solved · stability, formulation & IP.
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ELDICO Scientific AG, "The Electron Diffraction Company," stands at the forefront of Swiss technology and innovation. Established in 2019, ELDICO is dedicated to advancing scientific exploration with its groundbreaking electron diffractometer. This pioneering device empowers researchers to unravel the mysteries of the nanoscale world, providing precise answers to their inquiries. Through the development, production, and sale of this cutting-edge technology, ELDICO is shaping the future of particle analysis and driving progress in scientific discovery.
In 2022, ELDICO Scientific opened its Experience Centre for electron diffraction in Basel, Switzerland, showcasing its cutting-edge device, the ELDICO ED-1. Nestled within the Switzerland Innovation Park Basel, this center provides an exclusive platform for customers to delve into the world of electron diffraction. Here, they can access a range of services, including contract research, scientific application development, collaborative opportunities, and tailored training workshops. Our clientele primarily comprises researchers from industrial and R&D-intensive sectors, particularly in burgeoning fields such as pharmaceuticals, energy storage, and advanced materials.