Electron diffraction: advancing mechanical chemistry.
How microED found the crystal hiding in an amorphous drug–drug salt.
What you'll learn
- How microED characterises mechanochemical (grinding) products
- How a quininium aspirinate structure was solved from an apparently amorphous salt
- Why solid-state control matters across drug development and regulation
Why it matters
Solid-state behaviour is a critical, regulated part of drug development, and mechanochemistry increasingly delivers new salts and cocrystals that resist conventional analysis. This note shows how microED solved the crystal structure of a quininium aspirinate salt that had remained hidden in an amorphous drug–drug system.
At a glance: 3D ED / MicroED · quininium aspirinate · mechanochemical salt · crystal solved from amorphous material · solid-form control.
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ELDICO Scientific AG, "The Electron Diffraction Company," stands at the forefront of Swiss technology and innovation. Established in 2019, ELDICO is dedicated to advancing scientific exploration with its groundbreaking electron diffractometer. This pioneering device empowers researchers to unravel the mysteries of the nanoscale world, providing precise answers to their inquiries. Through the development, production, and sale of this cutting-edge technology, ELDICO is shaping the future of particle analysis and driving progress in scientific discovery.
In 2022, ELDICO Scientific opened its Experience Centre for electron diffraction in Basel, Switzerland, showcasing its cutting-edge device, the ELDICO ED-1. Nestled within the Switzerland Innovation Park Basel, this center provides an exclusive platform for customers to delve into the world of electron diffraction. Here, they can access a range of services, including contract research, scientific application development, collaborative opportunities, and tailored training workshops. Our clientele primarily comprises researchers from industrial and R&D-intensive sectors, particularly in burgeoning fields such as pharmaceuticals, energy storage, and advanced materials.