Completing the ritonavir polymorph landscape.
How 3D electron diffraction and crystal-structure prediction resolved a form that had eluded conventional characterisation.
What you'll learn
- How 3D ED delivers crystal structures directly from nanocrystalline material
- How ED and CSP combine to map a compound's accessible solid forms
- Why complete solid-form knowledge de-risks development and protects IP
Why it matters
Ritonavir is the textbook case of a late-appearing polymorph disrupting a marketed drug – knowing the full solid-form landscape early is how you avoid the surprise. This note shows how 3D ED, with crystal-structure prediction (CSP), completed ritonavir's polymorph landscape and resolved a form that had eluded conventional structural characterisation.
At a glance: 3D ED / MicroED + CSP · Ritonavir (antiretroviral) · nanocrystalline material · previously uncharacterised form resolved · solid-form de-risking & IP.
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ELDICO Scientific AG, "The Electron Diffraction Company," stands at the forefront of Swiss technology and innovation. Established in 2019, ELDICO is dedicated to advancing scientific exploration with its groundbreaking electron diffractometer. This pioneering device empowers researchers to unravel the mysteries of the nanoscale world, providing precise answers to their inquiries. Through the development, production, and sale of this cutting-edge technology, ELDICO is shaping the future of particle analysis and driving progress in scientific discovery.
In 2022, ELDICO Scientific opened its Experience Centre for electron diffraction in Basel, Switzerland, showcasing its cutting-edge device, the ELDICO ED-1. Nestled within the Switzerland Innovation Park Basel, this center provides an exclusive platform for customers to delve into the world of electron diffraction. Here, they can access a range of services, including contract research, scientific application development, collaborative opportunities, and tailored training workshops. Our clientele primarily comprises researchers from industrial and R&D-intensive sectors, particularly in burgeoning fields such as pharmaceuticals, energy storage, and advanced materials.