Working with micrograms instead of milligrams
Precision at the sub-microgram Scale
A leading pharmaceutical company approached us with a challenge—an HPLC fraction containing less than 1 mg of an unknown natural product.
The sample? A honey-like, gel-type substance, clearly not 100% pure, and difficult to analyse by any other analytical methods.
The challenge: obtaining structural information out of it.
Conventional methods were simply not an option.
At ELDICO Scientific, we specialize in high-precision crystallisatin and solid-state analysis and characterisation. Our advanced methodologies allow us to work with ultra-small samples, delivering unprecedented structural insights even from sub-microgram impure samples.
Using our expertise in micro-filtration and micro-crystallization, we successfully:
- Isolated the pure natural compound from a complex mixture.
- Crystallized less than 100 µg of sample directly onto a 3 mm TEM grid.
- Determined the structure of a new macro-cyclic natural compound via electron diffraction.
Expand Your Capabilities with ELDICO Scientific
Accelerate your research and push the boundaries of solid-state analysis with our cutting-edge approach.
Download the full case study 👉and find outhow we can help you if:
- You don’t have enough material available.
- You haven’t been able to isolate your compound of interest.
- You haven’t been able to crystallise yout desired molecule.
- You haven’t been able to structurally characterise your (new) compounds.
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ELDICO Scientific AG, "The Electron Diffraction Company," stands at the forefront of Swiss technology and innovation. Established in 2019, ELDICO is dedicated to advancing scientific exploration with its groundbreaking electron diffractometer. This pioneering device empowers researchers to unravel the mysteries of the nanoscale world, providing precise answers to their inquiries. Through the development, production, and sale of this cutting-edge technology, ELDICO is shaping the future of particle analysis and driving progress in scientific discovery.
In 2022, ELDICO Scientific opened its Experience Centre for electron diffraction in Basel, Switzerland, showcasing its cutting-edge device, the ELDICO ED-1. Nestled within the Switzerland Innovation Park Basel, this center provides an exclusive platform for customers to delve into the world of electron diffraction. Here, they can access a range of services, including contract research, scientific application development, collaborative opportunities, and tailored training workshops. Our clientele primarily comprises researchers from industrial and R&D-intensive sectors, particularly in burgeoning fields such as pharmaceuticals, energy storage, and advanced materials.